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1

Novel substituted pyrimidines as HCV replication (replicase) inhibitors

Cecil D. Kwong, Jeremy L. Clark, Anita T. Fowler, Feng Geng, Hollis S. Kezar III, Abhijit Roychowdhury, Robert C. Reynolds, Joseph A. Maddry, Subramaniam Ananthan, John A. Secrist III, Neng-Yang Shih,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 565 KB

english, 2012

2

[American Society of Civil Engineers Pipelines 2013 - Fort Worth, Texas, United States (June 23-26, 2013)] Pipelines 2013 - Performance Evaluation of Steel Fiber-Reinforced Concrete Pipe under D-Loads

Coombs, Shawn R., Kurdziel, John, Secrist, Derek

Year:

2013

Language:

english

File:

PDF, 1.04 MB

english, 2013

3

Synthesis and Biological Activity of 2′-Fluoro-D-arabinofuranosylpyrazolo[3,4-d]pyrimidine Nucleosides

Anita T. Shortnacy-Fowler, Kamal N. Tiwari, John A. Montgomery, Robert W. Buckheit, Jr., John A. Secrist III, Frank Seela

Journal:

Helvetica Chimica Acta

Year:

1999

Language:

english

File:

PDF, 91 KB

english, 1999

4

ChemInform Abstract: Synthesis and Biological Activity of 5-Azacytosine Nucleosides Derived from 4-Thio-2-deoxy-L-threo-pentofuranose and 4-Thio-2-deoxy-D-erythro-pentofuranose

Loredana Cappellacci, Kamal N. Tiwari, John A. Montgomery, John A. Secrist III

Journal:

Year:

1999

File:

PDF, 26 KB

1999

5

ChemInform Abstract: Synthesis and Biological Activity of 2′-Fluoro-D-arabinofuranosylpyrazolo[3,4-d]pyrimidine Nucleosides.

Anita T. Shortnacy-Fowler, Kamal N. Tiwari, John A. Montgomery, Robert W. Buckheit Jr., John A. Secrist III, Frank Seela

Journal:

Year:

2000

File:

PDF, 26 KB

2000

6

ChemInform Abstract: Certain 3,9-Dideazapurines as Inhibitors of Purine Nucleoside Phosphorylase.

Jerry D. Rose, John A. Secrist III, John A. Montgomery

Journal:

Year:

2000

File:

PDF, 31 KB

2000

7

ChemInform Abstract: Preclinical Antitumor Activity of 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine (Cl-F-Ara-A).

William R. Waud, Steven M. Schmid, John A. Montgomery, John A. Secrist III

Journal:

Year:

2000

File:

PDF, 28 KB

2000

8

ChemInform Abstract: Synthesis of 4′-Thio-β-D-arabinofuranosylcytosine (4′-Thio-ara-C) and Comparison of Its Anticancer Activity with that of Ara-C

Kamal N. Tiwari, Anita T. Shortnacy-Fowler, Loredana Cappellacci, William B. Parker, William R. Waud, John A. Montgomery, John A. Secrist III

Journal:

Year:

2000

File:

PDF, 33 KB

2000

9

ChemInform Abstract: A Convenient Synthesis of 2′-Deoxy-2-fluoroadenosine; a Potential Prodrug for Suicide Gene Therapy.

Abdalla E. A. Hassan, Anita T. Shortnacy-Fowler, John A. Montgomery, John A. Secrist III

Journal:

Year:

2000

File:

PDF, 31 KB

2000

10

ChemInform Abstract: Synthesis and Antiproliferative Activity of Some 4′-C-Hydroxymethyl-α- and -β-D-arabino-pentofuranosyl Pyrimidine Nucleosides

Jean-Francois Griffon, John A. Montgomery, John A. Secrist III

Journal:

Year:

2001

File:

PDF, 28 KB

2001

11

ChemInform Abstract: Synthesis and Biological Activity of 4′-Thio-L-xylofuranosyl Nucleosides

Kamal N. Tiwari, Lea Messini, John A. Montgomery, John A. Secrist III

Journal:

Year:

2001

File:

PDF, 25 KB

2001

12

ChemInform Abstract: Synthesis and Biological Activity of 4′-C-Hydroxymethyl-2′-fluoro-D-arabinofuranosylpurine Nucleosides.

Anita T. Shortnacy-Fowler, Kamal N. Tiwari, John A. Montgomery, John A. Secrist III

Journal:

Year:

2002

File:

PDF, 38 KB

2002

13

ChemInform Abstract: Convenient Syntheses of 6-Methylpurine and Related Nucleosides.

Abdalla E. A. Hassan, Reham A. I. Abou-Elkair, John A. Montgomery, John A. Secrist III

Journal:

Year:

2002

File:

PDF, 30 KB

2002

14

ChemInform Abstract: Synthesis and Structure—Activity Relationships of 5-Substituted-4′-thio-β-D-arabinofuranosylcytosines.

Kamal N. Tiwari, Anita T. Shortnacy-Fowler, Loredana Cappellacci, William R. Waud, William B. Parker, John A. Montgomery, John A. Secrist III

Journal:

Year:

2002

File:

PDF, 32 KB

2002

15

Selective Metalation of 6-Methylpurines: Synthesis of 6-Fluoromethylpurines and Related Nucleosides

Abdalla E. A. Hassan, William B. Parker, Paula W. Allan, John A. Montgomery, John A. III Secrist

Journal:

Year:

2004

File:

PDF, 54 KB

2004

16

Synthesis and Anticancer Activity of Some Novel 5-Azacytosine Nucleosides.

Kamal N. Tiwari, Loredana Cappellacci, John A. Montgomery, John A. III Secrist

Journal:

Year:

2004

File:

PDF, 103 KB

2004

17

ChemInform Abstract: Synthesis and Anticancer Evaluation of 4′-C-Methyl-2′-fluoro Arabino Nucleosides.

Kamal N. Tiwari, Anita T. Shortnacy-Fowler, William B. Parker, William R. Waud, John A. III Secrist

Journal:

Year:

2010

File:

PDF, 15 KB

2010

18

ChemInform Abstract: Regioselective Metalation of 6-Methylpurines: Synthesis of Fluoromethyl Purines and Related Nucleosides for Suicide Gene Therapy of Cancer

Abdalla E. A. Hassan, William B. Parker, Paula W. Allan, John A. III Secrist

Journal:

Year:

2010

File:

PDF, 30 KB

2010

19

α-(1 → 2)-, α-(1 → 3)-, and α-(1 → 6)-Linked thioglycosidic disaccharides: syntheses and anti-HIV testing of thiokojibiose octaacetate, thionigerose, and thioisomaltose

Robert N. Comber, Joyce D. Friedrich, David A. Dunshee, Sandra L. Petty, John A. Secrist III

Journal:

Carbohydrate Research

Year:

1994

Language:

english

File:

PDF, 877 KB

english, 1994

20

Clofarabine Acts as Radiosensitizer In Vitro and In Vivo by Interfering With DNA Damage Response

Mickael J. Cariveau, Murray Stackhouse, Xiao-li Cui, Kamal Tiwari, William Waud, John A. Secrist III, Bo Xu

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2008

Language:

english

File:

PDF, 731 KB

english, 2008

21

Designer Gene Therapy Using an Escherichia coli Purine Nucleoside Phosphorylase/Prodrug System

Eric M Bennett, Ruchi Anand, Paula W Allan, Abdalla E.A Hassan, Jeong S Hong, Dana N Levasseur, David T McPherson, William B Parker, John A Secrist III, Eric J Sorscher, Tim M Townes, William R Waud,

Journal:

Chemistry & Biology

Year:

2003

Language:

english

File:

PDF, 494 KB

english, 2003

22

A convenient procedure for formation of certain uracil and thymine anhydronucleosides

John A. Secrist III

Journal:

Carbohydrate Research

Year:

1975

Language:

english

File:

PDF, 150 KB

english, 1975

23

Enol acetates of nucleoside-5′-aldehydes: potential intermediates for substituent incorporation at C-4′

Steven L. Cook, John A. Secrist III

Journal:

Carbohydrate Research

Year:

1976

Language:

english

File:

PDF, 229 KB

english, 1976

24

Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine

Jolita Šečkutė, Diane E. McCloskey, H. Jeanette Thomas, John A. Secrist III, Anthony E. Pegg, Steven E. Ealick

Journal:

Protein Science

Year:

2011

Language:

english

File:

PDF, 777 KB

english, 2011

25

PNP inhibitors

John A. Montgomery, John A. Secrist

Journal:

Perspectives in Drug Discovery and Design

Year:

1994

Language:

english

File:

PDF, 1.25 MB

english, 1994

26

Preclinical antitumor activity of 4′-thio-β-d-arabinofuranosylcytosine (4′-thio-ara-C)

William R. Waud, Karen S. Gilbert, Rodney V. Shepherd, John A. Montgomery, John A. Secrist

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2003

Language:

english

File:

PDF, 225 KB

english, 2003

27

Lack of in vivo cross-resistance with 4′-thio-ara-C against drug-resistant murine P388 and L1210 leukemias

William R. Waud, Karen S. Gilbert, John A. Secrist

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 177 KB

english, 2011

28

The Alabama Drug Discovery Alliance: A Collaborative Partnership to Facilitate Academic Drug Discovery

Maaike Everts, W. Blaine Knight, David R. Harris, John A. Secrist, Richard J. Whitley

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 122 KB

english, 2011

29

Acyclic analogues of pyrazofurin: syntheses and antiviral evaluation

Robert N. Comber, Rita J. Gray, John A. Secrist III

Journal:

Carbohydrate Research

Year:

1992

Language:

english

File:

PDF, 954 KB

english, 1992

30

A Comparison of Solvent and Thermal Techniques for Determining the Fat Content of Ground Beef

DEXTER R. BELLIS, JOHN L. SECRIST, MICHAEL J. LINSKEY

Journal:

Journal of Food Science

Year:

1967

Language:

english

File:

PDF, 391 KB

english, 1967

31

EFFECTS OF SOY PARTICLE SIZE AND COLOR ON THE SENSORY PROPERTIES OF GROUND BEEF PATTIES

ARMAND V. CARDELLO, JOHN SECRIST, JOSEPH SMITH

Journal:

Journal of Food Quality

Year:

1983

Language:

english

File:

PDF, 1.01 MB

english, 1983

32

Discovery and development of clofarabine: a nucleoside analogue for treating cancer

Bonate, Peter L., Arthaud, Larry, Cantrell, William R., Stephenson, Katherine, Secrist, John A., Weitman, Steve

Journal:

Nature Reviews Drug Discovery

Year:

2006

Language:

english

File:

PDF, 549 KB

english, 2006

33

Antitumor activity of 2-fluoro-2′-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase

Parker, William B, Allan, Paula W, Hassan, Abdalla E A, Secrist, John A, Sorscher, Eric J, Waud, William R

Journal:

Cancer Gene Therapy

Year:

2003

Language:

english

File:

PDF, 153 KB

english, 2003

34

(.+-.)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)-(1.alpha.,2.alpha.,3.beta.,5.beta.)-1,2-cyclopentanediol, the carbocyclic analog of tubercidin

Secrist, John A., Clayton, Sarah Jo, Montgomery, John A.

Journal:

Journal of Medicinal Chemistry

Year:

1984

Language:

english

File:

PDF, 422 KB

english, 1984

35

Convenient synthesis of 9-methylbenzo[a]pyrene

Lyga, John W., Secrist, John A.

Journal:

Journal of Organic Chemistry

Year:

1979

Language:

english

File:

PDF, 459 KB

english, 1979

36

5,5-Disubstituted hydantoins: syntheses and anti-HIV activity

Comber, Robert N., Reynolds, Robert C., Friedrich, Joyce D., Manguikian, Roupen A., Buckheit, Robert W., Truss, Jackie W., Shannon, William M., Secrist, John A.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 774 KB

english, 1992

37

Studies directed toward a total synthesis of nucleoside Q. Annulation of 2,6-diaminopyrimidin-4-one with .alpha.-halo carbonyls to form pyrrolo[2,3-d]pyrimidines and furo[2,3-d]pyrimidines

Secrist, John A., Liu, Paul S.

Journal:

Journal of Organic Chemistry

Year:

1978

Language:

english

File:

PDF, 719 KB

english, 1978

38

Resolution of racemic carbocyclic analogs of purine nucleosides through the action of adenosine deaminase. Antiviral activity of the carbocyclic 2'-deoxyguanosine enantiomers

Secrist, John A., Montgomery, John A., Shealy, Y. Fulmer, O'Dell, C. Allen, Clayton, Sarah Jo

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 630 KB

english, 1987

39

Preclinical Antitumor Activity of 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine (C1-F-Ara-A)

Waud, William R., Schmid, Steven M., Montgomery, John A., Secrist, John A.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2000

Language:

english

File:

PDF, 629 KB

english, 2000

40

Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(Arylmethyl) derivatives of 9-deazaguanine

Montgomery, John A., Niwas, Shri, Rose, Jerry D., Secrist, John A., Babu, Y. Sudhakar, Bugg, Charles E., Erion, Mark D., Guida, Wayne C., Ealick, Steven E.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 3.31 MB

english, 1993

41

ChemInform Abstract: Synthesis and Evaluation of the Substrate Activity of C-6 Substituted Purine Ribosides with E. coli Purine Nucleoside Phosphorylase: Palladium Mediated Cross-Coupling of Organozinc Halides with 6-Chloropurine Nucleosides.

Abdalla E. A. Hassan, Reham A. I. Abou-Elkhair, James M. Riordan, Paula W. Allan, William B. Parker, Rashmi Khare, William R. Waud, John A. Montgomery, John A. III Secrist

Journal:

Year:

2012

Language:

english

File:

PDF, 35 KB

english, 2012

42

Recent development of therapeutics for chronic HCV infection

Zhuhui Huang, Michael G. Murray, John A. Secrist III

Journal:

Antiviral Research

Year:

2006

Language:

english

File:

PDF, 466 KB

english, 2006

43

In Vitro and In Vivo Efficacy of a Pyrimidine Nucleoside Analog Against Vaccinia and Cowpox Viruses

Debra Quenelle, Mark Prichard, Kathy Keith, Deborah Collins, Terri Rice, John Secrist, Kamal Tiwari, Joseph Maddry, Earl Kern

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

44

Combinations of 5-Iodo-4′-thio-2′-deoxyuridine and ST-246 or CMX001 Synergistically Inhibit Orthopoxvirus Replication In Vitro

Kathy Keith, Shalisa Sanders, Kamal Tiwari, Joseph Maddry, John Secrist, Robert Jordan, Dennis Hruby, Randall Lanier, George Painter, Earl Kern, Mark Prichard

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 83 KB

english, 2009

45

Mutation of the Thymidine Kinases Encoded by Herpes Simplex Virus or Vaccinia Virus can Confer Resistance to 5-Iodo-4′-thio-2′-deoxyuridine

Emma Harden, Kathy Keith, Shannon Daily, Kamal Tiwari, Joseph Maddry, John Secrist, Earl Kern, Mark Prichard

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 69 KB

english, 2009

46

Inhibition of Herpesvirus Replication With 5-Iodo-4′-Thio-2′-Deoxyuridine

Mark Prichard, Debra Quenelle, Caroll Hartline, Emma Harden, Geraldine Jefferson, Samuel Frederick, Terri Rice, Deborah Collins, Kamal Tiwari, Joseph Maddry, Richard Whitley, John Secrist, Earl Kern

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 71 KB

english, 2009

47

Activity of Certain 5-Substituted-4′-Thio Pyrimindine Nucleosides against Orthopoxvirus Infections

Earl Kern, Mark Prichard, Debra Quenelle, Kathy Keith, Kamal Tiwari, Joseph Maddry, John Secrist III

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 74 KB

english, 2009

48

Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: Palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides

Abdalla E.A. Hassan, Reham A.I. Abou-Elkhair, James M. Riordan, Paula W. Allan, William B. Parker, Rashmi Khare, William R. Waud, John A. Montgomery, John A. Secrist III

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 624 KB

english, 2012

49

Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity

Jessica J. O’Konek, Brendon Ladd, Sheryl A. Flanagan, Mike M. Im, Paul D. Boucher, Tico S. Thepsourinthone, John A. Secrist III, Donna S. Shewach

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2010

Language:

english

File:

PDF, 1.22 MB

english, 2010

50

High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv

Subramaniam Ananthan, Ellen R. Faaleolea, Robert C. Goldman, Judith V. Hobrath, Cecil D. Kwong, Barbara E. Laughon, Joseph A. Maddry, Alka Mehta, Lynn Rasmussen, Robert C. Reynolds, John A. Secrist II

Journal:

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

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